教 師 簡 歷
基本信息
照片/Photo🧙🏼♂️：
電子郵箱/E-mail👔：ylzoucau@163.com
個人簡介
鄒雲龍
博士，副教授，碩導
課程教學
本科生課程🕵️♀️：
《基因工程》🐮、《遺傳學》（英文）🐶、《生命科學前沿講座》（主持）
研究方向及課題
科研項目：主持國家自然科學基金青年基金項目、中央高校基本科研業務費
研究方向關鍵詞：基因編輯🧑🏽🦲、昆蟲化學感受、家蠶發育生物學
主要科研貢獻📲：
（1）高效基因編輯工具的開發與優化👲🏽。在家蠶中，建立了高效的基於核糖核蛋白的CRISPR/Cas9和CRISPR/Cas12a (Cpf1) 基因編輯系統。利用遺傳修飾手段（基因編輯🧗🏿♀️、轉基因）解析重要基因的功能、探究調控機製👨🦰🧑🏼🔬、創製育種素材❗️。
（2）眾所周知，家蠶主要以桑葉為食，對桑葉具有特殊的偏好。我們對其遺傳基礎及調控機製進行了深入研究，挖掘了多個參與家蠶食性調控的嗅覺受體❤️🔥、味覺受體、轉錄因子💍，並通過基因編輯創製了對人工飼料優異適應性的育種素材👨🏽🎨。
研究成果
發表論文 (#共同一作, *通訊作者)：
[1] Yunlong Zou; Wentao Wu; Tianfu Luo; Yuxia Tang; Hai Hu; Aijun Ye; Lifeng Xu; Fangyin Dai*; Xiaoling Tong*. Disruption of Zfh3 abolishes mulberry-specific monophagy in silkworm larvae, Insect Science, 2024, doi: 10.1111/1744-7917.13354.
[2] Yun-Long Zou#; Xin Ding#; Li Zhang#; Li-Feng Xu; Shu-Bo Liang; Hai Hu; Fang-Yin Dai; Xiao-Ling Tong*. Bmmp influences wing morphology by regulating anterior-posterior and proximal-distal axes development, Insect Science, 2022, 29(6):1569-1582.
[3] Yun-long Zou; Ai-jun Ye; Shuo Liu; Wen-tao Wu; Li-feng Xu; Fang-yin Dai; Xiao-ling Tong*. Expansion of targetable sites for the ribonucleoprotein-based CRISPR/Cas9 system in the silkworm Bombyx mori, BMC Biotechnology, 2021, 21(1): 54
[4] Yunlong Zou; Haiyang Hao; Ning Li; Qiuyan Li*. Establishment and characterization of immortalized porcine neonatal hepatocytes without the use of viral components, In Vitro Cellular & Developmental Biology-Animal, 2020, 56 (1): 75-84
[5] ZOU Yun-long; LI Zhi-yuan; ZOU Yun-jing; HAO Hai-yang; HU Jia-xiang; LI Ning; LI Qiu-yan*. Generation of pigs with a Belgian Blue mutation in MSTN using CRISPR/Cpf1-assisted ssODN-mediated homologous recombination, Journal of Integrative Agriculture, 2019, 18(6): 1329-1336
[6] Yunlong Zou; Zhiyuan Li; Yunjing Zou; Haiyang Hao; Ning Li; Qiuyan Li*. An FBXO40 knockout generated by CRISPR/Cas9 causes muscle hypertrophy in pigs without detectable pathological effects, Biochemical and Biophysical Research Communications, 2018, 498(4): 940-945
[7] Yunlong Zou; Yanjun Dong; Qingyong Meng; Yaofeng Zhao*; Ning Li*. Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IGF1 expression and induces skeletal muscle hypertrophy, Scientific Reports, 2018, 8(1): 2781
[8] Tingting Gai#; Xiaoling Tong#*; Minjin Han; Chunlin Li; Chunyan Fang; Yunlong Zou; Hai Hu; Hui Xiang; Zhonghuai Xiang; Cheng Lu; Fangyin Dai*. Cocoonase is indispensable for Lepidoptera insects breaking the sealed cocoon, PLoS Genetics, 2020, 16(9)
[9] Jingyao Chen; Haitao Wang; Jianhui Bai; Wenjie Liu; Xiaojuan Liu; Dawei Yu; Tao Feng; Zhaolin Sun; Linlin Zhang; Linyuan Ma; Yiqing Hu; Yunlong Zou; Tan Tan; Jie Zhong; Man Hu; Xiaofei Bai; Dengke Pan; Yiming Xing; Yaofeng Zhao; Kegong Tian*; Xiaoxiang Hu*; Ning Li*. Generation of Pigs Resistant to Highly Pathogenic-Porcine Reproductive and Respiratory Syndrome Virus through Gene Editing of CD163, International Journal of Biological Sciences, 2019, 15(2): 481-492
