王 峰
理學博士，研究員，碩士生導師
重慶市巴渝青年學者（2021）
重慶市蠶絲纖維新材料工程技術研究中心 副主任
一、教育與工作經歷
2023年---至 今，西南大學，研究員
2018年---2023年，西南大學，副教授
2018年---2019年，美國塔夫茨大學（Tufts University, U.S.），訪問學者
2016年---2018年，西南大學，助理研究員
2014年---2016年，西南大學，師資博士後
2008年---2014年，西南大學，理學博士
2004年---2008年，西南大學，工學學士
二、研究領域
1. 家蠶絲腺合成生物學與蛋白藥物研發
2. 醫用生物材料的開發與組織工程應用
3. 蠶絲固定化酶技術研發以及產品開發
三、研究成果
長期致力於家蠶絲腺生物反應器與蠶絲遺傳改良探索研究，積極推動家蠶及蠶絲在生物製藥和生物材料領域中的創新應用。
1、突破了家蠶絲腺生物反應器表達效率的瓶頸，優化建立了高效穩定的家蠶絲腺生物反應器合成系統，培育出高效表達人血清白蛋白、人乳鐵蛋白、人源生長因子、人胰島素等高附加值藥用蛋白的新型家蠶素材品系50余個；建立了蠶絲中外源蛋白的規模化分離純化技術體系，純化獲得多個毫克級高純度具有生物活性的重組蛋白，並完成其生物活性評價，證明家蠶絲腺具備合成功能性外源蛋白的能力，為家蠶絲腺生物反應器用於生物製藥和市場轉化奠定了理論基礎和技術保障。
2、建立了蠶絲遺傳改良關鍵技術體系，創新利用家蠶絲腺規模化生物合成功能性蠶絲原料，利用具有組織修復功能的20余種人源生長因子，以及具有抗腫瘤、抗氧化、抑製炎症等功能的10余種治療性重組蛋白對蠶絲進行遺傳改良，建立了可穩定遺傳的新型蠶絲家蠶素材品系庫。建立了功能性蠶絲生物材料製備技術，研發了具有促進組織修復功能的蠶絲膜、水凝膠和3D支架等生物材料，並在治療子宮內膜粘連，唇腭裂修復，定向成骨分化，血管修復，結腸炎治療，免疫力提升等醫學動物模型中展現優異的療效。相關成果得到央視和市級媒體的廣泛報道，並引起多家投資企業和醫療機構的高度關註。
3、以第一作者/通訊作者或參與者在Acta Biomaterialia（5次），ACS Appl Mater & Interfaces，Biomaterials Science（封面論文），Biosesensors and Bioelectronics等生物材料Top期刊上發表SCI論文50余篇，引用次數超過1200次。擁有國家發明專利10余項，專利轉讓5項。主持包括國家自然科學基金在內的科研項目10余個。獲2017年重慶市自然科學獎二等獎，2021年重慶市巴渝青年學者等獎項和稱號。多次受邀赴歐美，亞太及國內多所著名高校做學術報告，與國際國內蠶絲研究頂級團隊建立了長期穩定的合作關系。受邀擔任Biomaterials，Chemical Communications等十余個著名期刊審稿人。
四、發表論文 (Updated by Sep. 2023)
https://www.researchgate.net/profile/Feng-Wang-266/research
Selected publications:
1. First author, Co-first author (#), or corresponding author (*) publications
(17) Feng Wang, Ri-Yuan Wang, De-Bin Zhong, Ping Zhao, Qing-You Xia*. Highly efficient expression of human extracellular superoxide dismutase (rhEcSOD) with ultraviolet-B-induced damage-resistance activity in transgenic silkworm cocoons. Insect Science. 2023, 0, 1-15.
https://doi.org/10.1111/1744-7917.13289
(16) Huanhuan Tan,1 Yanting Ji,1 Hexu Lei,1 Fangyu Wang,1 Huan Dong,1 Shifeng Yang,1 Hongji Zhou,1 Hanxin Deng,1 Siyu Chen,1 David L. Kaplan,2 Qingyou Xia,1* Feng Wang1*. Large-scale and cost-effective production of recombinant human serum albumin (rHSA) in transgenic Bombyx mori cocoons. International Journal of Biological Macromolecules. 2023, 245, 125527.
https://doi.org/10.1016/j.ijbiomac.2023.125527
(15) Sheng Xu, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Huanhuan Tan, Ping Zhao, Qingyou Xia*, Feng Wang*. Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression. ACS Appl Mater Interfaces. 2021, 13(38): 45175-45190
https://doi.org/10.1021/acsami.1c08409
(14) Feng Wang#, Chengchen Guo#, Qianqian Yang, Chunmei Li, Ping Zhao, Qingyou Xia∗, David L. Kaplan∗. Protein composites from silkworm cocoons as versatile biomaterials. Acta Biomaterialia. 2021, 121: 180–192.
(13) Feng Wang*, Yan-Ting Ji, Chi Tian, Yuan-Cheng Wang, Shen Xu, Ri-Yuan Wang, Qian-Qian Yang, Ping Zhao, Qing-You Xia*. An inducible constitutive expression system in Bombyx mori mediated by phiC31 integrase. Insect Science. 2021, 28(5), 1277-1289.
https://onlinelibrary.wiley.com/doi/abs/10.1111/1744-7917.12866
(12) Feng Wang, Kai Hou, Wenjing Chen, Yuancheng Wang, Riyuan Wang, Chi Tian, Sheng Xu, Yanting Ji, Qianqian Yang, Ping Zhao, Ling Yu, Zhisong Lu, Huijie Zhang, Fushu Li, Han Wang, Baicheng He, David L. Kaplan*, Qingyou Xia*. Transgenic PDGF-BB/sericin hydrogel supports for cell proliferation and osteogenic differentiation. Biomaterials Science, 2020, 8(2), 657-672.
https://pubs.rsc.org/en/content/articlelanding/2019/bm/c9bm01478k#!divAbstract
(11) Yuancheng Wang, Sheng Xu, Riyuan Wang, Wenjing Chen, Kai Hou, Chi Tian, Yanting Ji, Qianqian Yang, Ling Yu, Zhisong Lu, Ping Zhao, Qingyou Xia*, Feng Wang*. Genetic Fabrication of Functional Silk Mats with Improved Cell Proliferation Activity for Medical Application. Biomaterials Science, 2019,7, 4536-4546. (Inside front cover)
https://pubs.rsc.org/en/content/articlelanding/2019/bm/c9bm01285k/unauth#!divAbstract
(10) Feng Wang, Yuancheng Wang, Chi Tian, Sheng Xu, Riyuan Wang, Kai Hou, Wenjing Chen, Ping Zhao, Ling Yu, Zhisong Lu, David L.Kaplan*, Qingyou Xia*. Fabrication of the FGF1-functionalized sericin hydrogels with cell proliferation activity for biomedical application using genetically engineered Bombyx mori (B. mori) silk. Acta Biomaterialia, 2018,79: 239-252.
https://www.sciencedirect.com/science/article/pii/S1742706118304987
(9) Feng Wang, Riyuan Wang, Yuancheng Wang, Ping Zhao, Qingyou Xia*. Large-scale production of bioactive recombinant human acidic fibroblast growth factor in transgenic silkworm cocoons. Scientific Reports. 2015, 5:16323.
http://www.nature.com/articles/srep16323
(8) Feng Wang, Riyuan Wang, Yuancheng Wang, Hanfu Xu, Sanyuan Ma, Lin Yuan, Huan Ding, Ping Zhao, Qingyou Xia*. Remobilizing deleted piggyBac vector post integration for transgene stability in silkworm. Mol Genet Genomics. 2015, 290 (3):1181-1189.
http://link.springer.com/article/10.1007/s00438-014-0982-6
(7) Feng Wang, Hanfu Xu, Yuancheng Wang, Riyuan Wang, Lin Yuan, Huan Ding, Chunnuan Song, Zhixin Peng, Zhangchuan Peng, Sanyuan Ma, Ping Zhao, Qingyou Xia*. Advanced silk material spun by a transgenic silkworm promotes cell proliferation for biomedical application. Acta Biomaterialia, 2014, 10(12): 4947-4955.
http://www.sciencedirect.com/science/article/pii/S1742706114002876
(6) Feng Wang, Hanfu Xu, Lin Yuan, Sanyuan Ma, Yuancheng Wang, Xiaoli Duan, Jianping Duan, Zhonghuai Xiang, Qingyou Xia*. An optimized sericin-1 expression system for mass-producing recombinant proteins in the middle silk glands of transgenic silkworms. Transgenic Res. 2013, 22(5): 925-38.
http://link.springer.com/article/10.1007/s11248-013-9695-6
(5) Feng Wang, Sanyuan Ma, Hanfu Xu, Jianping Duan, Yuancheng Wang, Huan Ding, Yuanyuan Liu, Xiaogang Wang, Ping Zhao, Qingyou Xia*. High-efficiency system for construction and evalsuation of customized TALENs for silkworm genome editing. Mol Genet Genomics. 2013, 288(12):683-90.
http://link.springer.com/article/10.1007/s00438-013-0782-4
(4) Yuancheng Wang#, Feng Wang#, Sheng Xu, Riyuan Wang, Wenjing Chen, Kai Hou, Chi Tian, Fan Wang, Ling Yu, Zhisong Lu, Ping Zhao, Qingyou Xia *. Genetically engineered bi-functional silk material with improved cell proliferation and anti-inflammatory activity for medical application. Acta Biomaterialia. 2019, 86, 148-157.
https://www.sciencedirect.com/science/article/pii/S174270611830761X
(3) Yuancheng Wang#, Feng Wang#, Sheng Xu, Riyuan Wang, Wenjing Chen, Kai Hou, Chi Tian, Fan Wang, Ping Zhao, Qingyou Xia*. Optimization of a 2A self-cleaving peptide-based multigene expression system for efficient expression of upstream and downstream genes in silkworm. Molecular Genetics and Genomics. 2019, 294: 849-859.
https://doi.org/10.1007/s00438-019-01534-2
(2) Sheng Xu#, Feng Wang#, Yuancheng Wang, Riyuan Wang, Kai Hou, Chi Tian, Yanting Ji, Qianqian Yang, Ping Zhao and Qingyou Xia*. A silkworm based silk gland bioreactor for high-efficiency production of recombinant human lactoferrin with antibacterial and anti-inflammatory activities. Journal of Biological Engineering, 2019,13:61.
https://doi.org/10.1186/s13036-019-0186-z
(1) Yuancheng Wang#, Feng Wang#, Riyuan Wang, Ping Zhao, Qingyou Xia*. 2A self-cleaving peptide-based multi-gene expression system in the silkworm Bombyx mori. Scientific Reports. 2015, 5:16273.
http://www.nature.com/articles/srep16273
2. Joint-publications
(29) Rongwei Gao, Xuelian Yang, Qiuju Yang, Yuanke Wu, Feng Wang, Qingyou Xia & Shu-Juan Bao*. Design of an amperometric glucose oxidase biosesensor with added protective and adhesion layers. Microchimica Acta, 2021, 188, 312.
(28) Weizhen Sun, Caroline S. Taylor, Yi Zhang, David A. Gregory, Mhd Anas Tomeh, John W. Haycock, Patrick J. Smith, Feng Wang, Qingyou Xia, Xiubo Zhao*. Cell guidance on peptide micropatterned silk fibroin scaffolds. Journal of Colloid and Interface Science. 2021, 603: 380–390.
(27) Xiaobai Li, Linxiang Wang, Gang Xiao, Yan Qiao, Feng Wang, Qingyou Xia, Ling Yu*, Zhisong Lu*. Adhesive tape-assisted etching of silk fibroin film with LiBr aqueous solution for microfluidic devices. Materials Science & Engineering C. 2021, 118: 111543.
(26) Yuancheng Wang, Feng Wang, Sheng Xu, Riyuan Wang, Chi Tian, Yanting Ji, Qianqian Yang, Ping Zhao, Qingyou Xia*. Transdermal peptide conjugated to human connective tissue growth factor with enhanced cell proliferation and hyaluronic acid synthesis activities produced by a silkworm silk gland bioreactor. Applied Microbiology and Biotechnology (2020) 104:9979–9990.
(25) Jingjing Fu, Xiao Bai Li, Lin Xiang Wang, Xiao Hui Lv, Zhisong Lu, Feng Wang, Qingyou Xia, Ling Yu* and Chang Ming Li*. One-Step Dip-Coating-Fabricated Core–Shell Silk Fibroin Rice Paper Fibrous Scaffolds for 3D Tumor Spheroid Formation. ACS Appl. Bio Mater. 2020, 3, 7462−7471.
(24) Ying Wang, Deng Wang, Li-Hong Sun, Long-Cheng Zhang, Zhi-Song Lu, Peng Xue, Feng Wang, Qing-You Xia, and Shu-Juan Bao*. BC@DNA-Mn3(PO4)2 Nanozyme for Real-Time Detection of Superoxide from Living Cells. Anal. Chem. 2020, 92, 24, 15927–15935
(23) Yan Fang Cheng, Yi Hong Mei, Gnanasekar Sathishkumar, Zhi Song Lu,⁎, Chang Ming Li, Feng Wang, Qing You Xia, Li Qun Xu*. Tannic acid-assisted deposition of silk sericin on the titanium surfaces for antifouling application. Colloid and Interface Science Communications. 2020, 35, 100241.
(22) Gang Xiao, Jing He, Yan Qiao, Feng Wang, Qingyou Xia, Xin Wang, Ling Yu*, Zhisong Lu* & Chang-Ming Li. Facile and Low-Cost Fabrication of a Thread/Paper-Based Wearable System for Simultaneous Detection of Lactate and pH in Human Sweat. Advanced Fiber Materials. 2020, 2: 265-278.
(21) Zhou Y, Lu X, Yang H, Chen Y, Wang F, Li J, Tang Z, Cheng X, Yang Y, Xu L, Xia Q. Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological evalsuations. Molecules. 2019 Nov 20;24(23):4217. doi: 10.3390/molecules24234217.
(20) Zhangchuan Peng; Xi Yang; Chun Liu; Zhaoming Dong; Feng Wang; Xin Wang; Wenbo Hu; Xia Zhang; Ping Zhao; Qingyou Xia*. Structural and Mechanical Properties of Silk from Different Instars of Bombyx mori. Biomacromolecules, 2019, 20 (3), pp 1203–1216. https://pubs.acs.org/doi/10.1021/acs.biomac.8b01576
(19) Ying Wang, Deng Wang, Li-Hong Sun, Peng Xue, Min-Qiang Wang, Zhisong Lu, Feng Wang, Qingyou Xia, Mao-Wen Xu, Shu-Juan Bao*. Constructing high effective nano-Mn3(PO4)2-chitosan in situ electrochemical detection interface for superoxide anions released from living cell. Biosesensors and Bioelectronics. Volume 133, 15 May 2019, Pages 133-140. https://www.sciencedirect.com/science/article/pii/S0956566319302325?dgcid=coauthor
(18) Lina Liu, Yejing Wang, Yu Li, Pengchao Guo, Chun Liu, Zhiqing Li, Feng Wang, Ping Zhao, Qingyou Xia, Huawei He*. Insights into the repression of fibroin modulator binding protein-1 on the transcription of fibroin H-chain during molting in Bombyx mori. Insect Biochem Mol Biol. Volume 104, January 2019, Pages 39-49.
https://www.sciencedirect.com/science/article/pii/S0965174818302996
(17) Ying Zhou, Jing-Jing Fu, Lin-Xiang Wang, Zhisong Lu, Feng Wang, Qingyou Xia, Yuejun Kang, Chang Ming Li & Ling Yu*. Freeze-drying prepared ready-to-use gelatin @polypropylene nonwoven hybrid sheet for stacking 3D cell culture. Cellulose, 2019,26: 6755–6768.
https://link.springer.com/article/10.1007%2Fs10570-019-02545-3
(16) Gang Xiao, Jing He, Xiaodie Chen, Yan Qiao, Feng Wang, Qingyou Xia, Ling Yu* & Zhisong Lu*. A wearable, cotton thread/paper-based microfluidic device coupled with smartphones for sweat glucose sensing. Cellulose. 2019, 26: 4553-4562.
https://link.springer.com/article/10.1007/s10570-019-02396-y
(15) Guorong Hou, Yanjing Yun, Minqiang Wang, Ying Wang, Hao Chen, Longcheng Zhang, Feng Wang, Qingyou Xia, Yang Liu, Zhisong Lu* & Shu-Juan Bao*. A coaxial nanocable textured by a cerium oxide shell and carbon core for sensing nitric oxide. Microchimica Acta, 2019, 186:789.
https://link.springer.com/article/10.1007/s00604-019-3839-1
(14) Wenjing Chen, Feng Wang, Chi Tian, Yuancheng Wang, Sheng Xu, Riyuan Wang, Kai Hou, Ping Zhao, Ling Yu, Zhisong Lu, and Qingyou Xia*. Transgenic Silkworm-Based Silk Gland Bioreactor for Large Scale Production of Bioactive Human Platelet-Derived Growth Factor (PDGF-BB) in Silk Cocoons. Int. J. Mol. Sci. 2018, 19(9), 2533.
https://doi.org/10.3390/ijms19092533
(13) Huihui Zhang, Zhuanzhuan Shi, Mengyao Zhou, Feng Wang, Qingyou Xia, Yan Qiao, Ling Yu and Zhisong Lu*. Cohesive thermoplastic-assisted patterning and assembly of a textile-supported piezoresistive sensor for monitoring human vital signs. Smart Mater. Struct. 2018. 27: 105027.
http://iopscience.iop.org/article/10.1088/1361-665X/aadb63/meta
(12) Zicong Zhao, Bintian Li, Liqun Xu, Yan Qiao, Feng Wang, Qingyou Xia and Zhisong Lu*. A Sandwich-Structured Piezoresistive Sensor with Electrospun Nanofiber Mats as Supporting, Sensing, and Packaging Layers. Polymers 2018, 10(6), 575.
https://doi.org/10.3390/polym10060575
(11) Jianping Duan, Xianxin Meng, Sanyuan Ma, Feng Wang, Huozhen Guo, Liying Zhang, Ping Zhao, Yunchao Kan, Lunguang Yao, Qingyou Xia*. The C-terminus of DSXF5 protein acts as a novel regulatory domain in Bombyx mori. Transgenic Res. 2016 Mar 15.
http://link.springer.com/article/10.1007/s11248-016-9946-4
(10) Hanfu Xu, Lin Yuan, Feng Wang, Yuancheng Wang, Riyuan Wang, Chunnuan Song, Qingyou Xia, Ping Zhao. Overexpression of recombinant infectious bursal disease virus (IBDV) capsid protein VP2 in the middle silk gland of transgenic silkworm. Transgenic Res. 2014, 23(5): 809-816.
http://link.springer.com/article/10.1007/s11248-014-9827-7
(9) Hanfu Xu, Yaowen Liu, Feng Wang, Lin Yuan, Yuancheng Wang, Sanyuan Ma, Helen Beneš, QingYou Xia*. Overexpression and functional characterization of an Aspergillus niger phytase in the fat body of transgenic silkworm, Bombyx mori. Transgenic Res. 2014, 23(4): 669-677.
http://link.springer.com/article/10.1007/s11248-014-9797-9
(8) Jianping Duan, Hanfu Xu, Shangyuan Ma, Huizheng Guo, Feng Wang, Liying Zhang, Xingfu Zha, Ping Zhao and Qingyou Xia*. Ectopic expression of the male BmDSX affects formation of the chitin plate in female Bombyx mori. Mol Reprod Dev. 2014 Mar; 81(3): 240-7.
http://onlinelibrary.wiley.com/doi/10.1002/mrd.22290/full
(7) Hanfu Xu, Dangjun Deng, Lin Yuan, Yuancheng Wang, Feng Wang, Qingyou Xia*. Identification of a functional element in the promoter of the silkworm (Bombyx mori) fat body-specific gene Bmlp3. Gene, 2014, 546(1): 129-134.
http://www.sciencedirect.com/science/article/pii/S0378111914006015
(6) Jianping Duan, Hanfu Xu, Huizhen Guo, David A. O'Brochta, Feng Wang, Sanyuan Ma, Liying Zhang, Xingfu Zha, Ping Zhao, Qingyou Xia*. New insights into the genomic organization and splicing of the doublesex gene, a terminal regulator of sexual differentiation in the silkworm Bombyx mori. PLoS One. 2013 Nov 7; 8(11): e79703. Doi: 10.1371/journal.pone.0079703.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079703
(5) DangJun Deng, HanFu Xu, Feng Wang, Xiaoli Duan, SanYuan Ma, ZhongHuai Xiang & QingYou Xia. The promoter of Bmlp3 gene can direct fat body-specific expression in the transgenic silkworm, Bombyx mori. Transgenic Res. 2013 Oct; 22(5): 1055-63.
http://link.springer.com/article/10.1007/s11248-013-9705-8
(4) Sanyuan Ma, Xiaogang Wang, Jitao Fei, Yuanyuan Liu, Jianping Duan, Feng Wang, Hanfu Xu, Ping Zhao, Qingyou Xia*. Genetic marking of sex using a W chromosome-linked transgene. Insect Biochem Mol Biol. 2013 Dec; 43(12):1079-86.
http://www.sciencedirect.com/science/article/pii/S0965174813001562
(3) Jianping Duan, Hanfu Xu, Sanyuan Ma, Huizhen Guo, Feng Wang, Ping Zhao, Qingyou Xia*. Cre-mediated targeted gene activation in the middle silk glands of transgenic silkworms. Transgenic Res. 2013 Jun; 22(3): 607-19.
http://link.springer.com/article/10.1007/s11248-012-9677-0
(2) Jianping Duan, Hanfu Xu, Feng Wang, Sanyuan Ma, Xingfu Zha, Huizhen Guo, Ping Zhao, Qingyou Xia*. Novel female-specific trans-spliced and alternative splice forms of dsx in the silkworm Bombyx mori. Biochemical and Biophysical Research Communications. 431 (2013) 630–635.
http://www.sciencedirect.com/science/article/pii/S0006291X12024102
(1) Sanyuan Ma, Shengling Zhang, Feng Wang, Yong Liu, Yuanyuan Liu, Hanfu Xu, Chun Liu, Ying Lin, Ping Zhao, Qingyou Xia*. Highly efficient and precise genome editing in silkworm using custom TALENs. PLoS One. September 18, 2012. 7(9): e45035. (High citation article)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045035
歡迎對本研究方向感興趣，並且具有生物、生物醫學、化學、材料或物理背景的學生和博士後加入我們，請通過電子郵件聯系並附上簡歷。
聯系地址:重慶市北碚區西南大學（南區）蠶學宮，400715
Email: atp_bomb@163.com或wangf1986@yggyf.cn
